After
a median of 39 months of treatment and an additional 38
months of posttrial observational followup, 341 participants
(10.0%) who received folic acid plus vitamin B(12) versus
288 participants (8.4%) who did not receive such treatment
were diagnosed with cancer (hazard ratio (HR) = 1.21; 95%
confidence interval (CI) = 1.03–1.41;