Conclusions: NaCl inhibited the growth of all isolates and killed 38% of tested isolates within concentration range currently
used in therapeutics. Our results suggest that anti-pseudomonal activity is another mechanism of action of HTS to add to
those already established. Clinical trials are needed to compare diverse HTS conditions of use (rhythm, dose and mode of
delivery) to obtain efficient and optimized anti-P. aeruginosa effects. More generally, NaCl effect on other opportunistic
pathogens as well as on global microbiotae recovered during polymicrobial diseases warrants further investigations