Malaria Liver is the major regulator of plasma glucose levels in the post absorptive state, and in type II diabetes hepatic glucose production is significantly elevated relative to nondiabetes. Glycogen phosphorylase, a key enzyme in the regulation of glycogen metabolism, catalyzes the degradative phosphorolysis of glycogen to glucose 1- phosphate. Glycogen phosphorylase has been exploited as a specific target of inhibitors that might prevent glycogenolysis under high glucose level conditions in type II diabetes1,2.