However, pretreatment with KRGE did not completely prevent busulfan-induced damage to the male reproductive system. Therefore, if KRGE is used with other agents that attenuate the adverse effects of anticancer agents, it might be possible to achieve additive or synergic effects for reduction of the adverse effects of anticancer agents. In this study, it was also observed that compared with vehicle control, treatment with busulfan alone caused pro- found atrophy and histological damage to the testis