Into the Future: Tools in Development for Manipulation of the Epigenome
The ability to selectively control DNA methylation levels at a single gene will be a truly transfor-
mative development for both neuroscience and epigenetics. For example, such a tool may enable
derepression of imprinted gene loci, controlled expression of developmentally regulated genes,
reversal of inherited epigenetic traits, selective restoration of genes critical to cognitive function in
disease states, and perhaps even modulation of selected behavioral memories that are maintained
by specific methylation profiles within defined brain circuits. With this in mind, this section ex-
amines some promising candidates for epigenetic control that provide some of the benefits that
are currently absent in epigenetic pharmacology.
Into the Future: Tools in Development for Manipulation of the EpigenomeThe ability to selectively control DNA methylation levels at a single gene will be a truly transfor-mative development for both neuroscience and epigenetics. For example, such a tool may enablederepression of imprinted gene loci, controlled expression of developmentally regulated genes,reversal of inherited epigenetic traits, selective restoration of genes critical to cognitive function indisease states, and perhaps even modulation of selected behavioral memories that are maintainedby specific methylation profiles within defined brain circuits. With this in mind, this section ex-amines some promising candidates for epigenetic control that provide some of the benefits thatare currently absent in epigenetic pharmacology.
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