The results revealed that sample CF retained more KA and has a texture profile with a high hardness and cohesiveness, which prevents good product application and produces sensory pleasantness. Sample AF provided good retention of KA for the skin but showed low values of hardness and viscosity, making the administration of the product difficult. Sample BF had a texture profile and bioadhesion suitable for topical use, and its permeation and skin retention demonstrated that this formulation helps modulate the permeation of KA, allowing for its controlled release.As we have observed, the results suggest that the pro- posed system is feasible for the incorporation of KA and its controlled release and that the most viable system for the incorporation of KA is system BF. The in vitro cytotoxic assays showed that KA-unloaded LCS and KA-loaded LCS do not present cytotoxicity. Therefore, PPG-5-CETETH-20- based systems may be a promising platform for KA skin delivery and to treat topical hyperpigmentation and skin