The development of different nanocomposites based on PLA with nanoclays has been extensively reported by several authors in the last years. However, few works have reported the combination of natural active additives and nanofillers in biopolymer matrices resulting in nano-biocomposites with antioxidant properties and functionalities for use in food packaging applications. The use of these materials could be a promising alternative to enhance mechanical and gas barrier properties and extend foodstuff shelflife.