propentofylline ihhibits reuptake of the neuromodulator modulator adenosine, resulting in extracellular accumulation of this molecule and potentiation of the neuroproprotective effect which it exerts via adenosine sine A1 and a2 receptor (inhibition of excitatoryamino acid release, vasodilatory and antithrombotic effect leading to tncreased cerebral blood flow and inhibition of neutrophil actvation. paradoxically, propentofylline also directly an
agonises adenosine receptor, but the clinical relevance of this activity remains unclear