A specific type of enteroendocrine cell, the enterochromaffin
(EC) cell that stores and releases 5-hydroxytryptamine
(i.e., serotonin), has been implicated
in the pathogenesis of irritable bowel syndrome (IBS).
However, there is a considerable patient-to-patient heterogeneity
of changes in EC cells (Mawe et al., 2006).
Several studies have focused on the serotonin-selective
transporter (SERT) that pumps released serotonin
back into EC cells and removes circulating serotonin
into platelets (Spiller, 2008; Faure et al., 2010). Although
SERT
A specific type of enteroendocrine cell, the enterochromaffin
(EC) cell that stores and releases 5-hydroxytryptamine
(i.e., serotonin), has been implicated
in the pathogenesis of irritable bowel syndrome (IBS).
However, there is a considerable patient-to-patient heterogeneity
of changes in EC cells (Mawe et al., 2006).
Several studies have focused on the serotonin-selective
transporter (SERT) that pumps released serotonin
back into EC cells and removes circulating serotonin
into platelets (Spiller, 2008; Faure et al., 2010). Although
SERT
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