There is no doubt that the DNA and chromosomes are considered to be the most exciting and important part of the cell nucleus. However, a vital and sometimes overlooked part of the cell nucleus is the nuclear lamina.
The term lamina is used in many fields including geology, botany, and physiology. Lamina (laminae – plural) means a very thin layer or plate. In geology it refers to the thinnest layer in a sedimentary rock that is different from other layers. In botany lamina can refer to a thin leaf or blade. In physiology lamina is used for the thin layers in bone. It is even used to describe the thin layers found in a horses hoof. In cell biology, lamina, specifically nuclear lamina refers to a complex mesh of intermediate fibers known as lamins and a number of lamin associated membrane proteins.
Among the lamin associated membrane proteins are: emerin, otefin, lamin B-receptor (LBR), lamin associated polypeptide 1 and 2 (LAP1 and LAP2) and MAN1 (also known as LEMD3). These proteins play an important role in the attachment of the nuclear lamina to the inner nuclear membrane.
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