of BMD occurred during the first 18–24 months of DMPA
use, and the majority of participants were exposed for at least
this duration of treatment. Therefore, the observations noted
here probably reflect the extent of loss experienced by most
DMPA users. It should also be noted that the study
population did not include adolescents who were immobilized,
had congenital bone diseases, or took medications that
impair bone metabolism; therefore, the study findings may
not be applicable to such adolescents. Despite these
limitations, this largest prospective study to date provides
reassuring evidence for reversibility of bone loss associated
with DMPA use when its use is discontinued.
of BMD occurred during the first 18–24 months of DMPAuse, and the majority of participants were exposed for at leastthis duration of treatment. Therefore, the observations notedhere probably reflect the extent of loss experienced by mostDMPA users. It should also be noted that the studypopulation did not include adolescents who were immobilized,had congenital bone diseases, or took medications thatimpair bone metabolism; therefore, the study findings maynot be applicable to such adolescents. Despite theselimitations, this largest prospective study to date providesreassuring evidence for reversibility of bone loss associatedwith DMPA use when its use is discontinued.
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