Spray freeze drying (SFD) provides a separation process that can produce porous particles whose physical and chemical characteris- tics are considered to be ideal for use in pulmonary drug delivery, the production of powders for epidermal immunization, in the pro- cessing of low water soluble drugs, the preparation of particles for microencapsulation, the processing of particles for use in chemical catalysis and biocatalysis, the preparation of nanopowders and ceramic electronic parts, in the cryogenic processing of chemicals and powder based materials, in the production of high value por- ous food particles, and in the synthesis of Li-ion battery cathode materials [1–7]. SFD involves the packing of frozen particles in con- tainers and, thus, a packed bed [2,3,7–13] of frozen particles is formed which has a porous structure and makes the frozen region of the material to be unsaturated during primary drying [2] because the space of the frozen region formed by the packed frozen particles is partially filled with gas (inert gas and solvent (e.g., water) vapor) which moves through the pores of the unsaturated porous frozen region by convection, Knudsen diffusion, and bulk diffusion during primary drying, as per Fig. 1a. During secondary drying, the bound (sorbed) solvent (e.g., water) is desorbed from the surface of the pores of the particles being dried and is trans- ported through the pores of the porous structure of the particles