Purpose/Objective: To explore patterns of symptoms be-fore and after surgery for cancer of the esophagus. Design: Longitudinal, descriptive study. Setting: An urban comprehensive cancer center in the northeastern United States. Sample: 218 patients with cancer of the esophagus under-going esophagectomy. Methods: Symptoms were assessed by self-report before surgery, at the first postoperative visit, and at 6 and 12 months postsurgery. Main Research Variables: Symptoms and demographic and clinical variables, including stage, treatment, gender, and comorbidities. Findings: Patients with esophageal cancer reported nu-merous symptoms before and after esophagectomy. Sev-eral patterns of symptoms were identified. General cancer symptoms (e.g., pain, cough, shortness of breath, weight loss) were reported as worse after surgery but recovered to baseline by one year. A second pattern of esophageal-specific symptoms (feeling full too quickly, feeling bloated, nausea, and diarrhea) worsened after surgery and did not recover to baseline by one year. Reflux was the only symptom that did not worsen after surgery but did worsen significantly during the first year of recovery. Conclusions: Patients with esophageal cancer experienced multiple prolonged symptoms following surgical treatment for their disease. General cancer symptoms resolved by one year post-treatment, whereas esophageal-specific symptoms worsened after surgery and did not recover to baseline. Implications for Nursing: Identification of symptom pat-terns preoperatively and during recovery can assist nurses in developing intervention protocols to minimize long-term complications for patients with esophageal cancer. . Knowledge Translation: Patients with esophageal cancer are at risk for multiple prolonged symptoms following sur-gery. Symptom assessment should occur often after surgery and include a broad range of symptoms.