harmacokinetics:
Absorption: 20-80% (oral). Absorption depends on the presence of bile and on normal pancreatic function; decrease with increasing dose.
Distribution: Enters blood via the chylomicrons in the lymph; bound to β-lipoproteins. Widely distributed to all tissues. Stored in adipose tissue. Enters breast milk but crosses the placenta poorly.
Metabolism: Hepatic; converted to glucuronides of tocopheronic acid and its γ-lactone.
Excretion: Excreted mainly via bile into faeces and some into urine.