of the Chinese medicinal mushrooms, are entomopathogenic and Ascomycotina. They are generally called “Tochukaso” in Japanense, meaning “winter-insect and summer-plant” because of their following behavior: (i) their spores enter into a specific living insect; (ii) they kill the host by feeding on it, and their hyphae grow in it; (iii) they pass the winter inside the host and eventually form fruiting bodbodies on the surface of the host insect’s cadaver in the summer. Some Cordyceps sp. have long been used to promote longevity, relieve exhaustion and treat numerous illnesses by acting as ahemostatic, a mycolytic, an anti-asthmatic and a hypoglycemic agents in Chinese traditional medicines [1–3]. They could produce
many kinds of bioactive compounds such as cordycepin, ophiocordin and some polysaccharides (1). Fungi are a valuable source for biotechnology application and have been receiving great interest Cordyceps militaris is produces various bioactive compounds, among which cordycepin (3'-deoxyadenosine) is a major active one. As an adenosine analogue, cordycepin has been reported to exhibit some significant pharmacological functions, including immunomodulatory, anti-inflammatory, anti-tumor, anti-metastatic and anti-bacterial activities (2). In this work, the effect of ferrous sulfate addition on cordycepin production was studied in shake flask cultures. Intermediate accumulation and transcription levels of three genes encoding adenylosuccinate synthetase, IMP cyclohydrolase and IMP dehydrogenase in the purine nucleotide pathway were also investigated. The information obtained would be beneficial not only to large-scale production but also to further manipulation and understanding of the cordycepin biosynthesis in future
of the Chinese medicinal mushrooms, are entomopathogenic and Ascomycotina. They are generally called “Tochukaso” in Japanense, meaning “winter-insect and summer-plant” because of their following behavior: (i) their spores enter into a specific living insect; (ii) they kill the host by feeding on it, and their hyphae grow in it; (iii) they pass the winter inside the host and eventually form fruiting bodbodies on the surface of the host insect’s cadaver in the summer. Some Cordyceps sp. have long been used to promote longevity, relieve exhaustion and treat numerous illnesses by acting as ahemostatic, a mycolytic, an anti-asthmatic and a hypoglycemic agents in Chinese traditional medicines [1–3]. They could producemany kinds of bioactive compounds such as cordycepin, ophiocordin and some polysaccharides (1). Fungi are a valuable source for biotechnology application and have been receiving great interest Cordyceps militaris is produces various bioactive compounds, among which cordycepin (3'-deoxyadenosine) is a major active one. As an adenosine analogue, cordycepin has been reported to exhibit some significant pharmacological functions, including immunomodulatory, anti-inflammatory, anti-tumor, anti-metastatic and anti-bacterial activities (2). In this work, the effect of ferrous sulfate addition on cordycepin production was studied in shake flask cultures. Intermediate accumulation and transcription levels of three genes encoding adenylosuccinate synthetase, IMP cyclohydrolase and IMP dehydrogenase in the purine nucleotide pathway were also investigated. The information obtained would be beneficial not only to large-scale production but also to further manipulation and understanding of the cordycepin biosynthesis in future
การแปล กรุณารอสักครู่..

of the Chinese medicinal mushrooms, are entomopathogenic and Ascomycotina. They are generally called “Tochukaso” in Japanense, meaning “winter-insect and summer-plant” because of their following behavior: (i) their spores enter into a specific living insect; (ii) they kill the host by feeding on it, and their hyphae grow in it; (iii) they pass the winter inside the host and eventually form fruiting bodbodies on the surface of the host insect’s cadaver in the summer. Some Cordyceps sp. have long been used to promote longevity, relieve exhaustion and treat numerous illnesses by acting as ahemostatic, a mycolytic, an anti-asthmatic and a hypoglycemic agents in Chinese traditional medicines [1–3]. They could produce
many kinds of bioactive compounds such as cordycepin, ophiocordin and some polysaccharides (1). Fungi are a valuable source for biotechnology application and have been receiving great interest Cordyceps militaris is produces various bioactive compounds, among which cordycepin (3'-deoxyadenosine) is a major active one. As an adenosine analogue, cordycepin has been reported to exhibit some significant pharmacological functions, including immunomodulatory, anti-inflammatory, anti-tumor, anti-metastatic and anti-bacterial activities (2). In this work, the effect of ferrous sulfate addition on cordycepin production was studied in shake flask cultures. Intermediate accumulation and transcription levels of three genes encoding adenylosuccinate synthetase, IMP cyclohydrolase and IMP dehydrogenase in the purine nucleotide pathway were also investigated. The information obtained would be beneficial not only to large-scale production but also to further manipulation and understanding of the cordycepin biosynthesis in future
การแปล กรุณารอสักครู่..
