Malabsorptive diarrhea
Decreased absorption of solutes from the lumen occurs in villus atrophy, just because there is not enough surface area to do the required work. The solutes and electrolytes that are not absorbed
cause water to be osmotically attracted into the lumen from the mucosa, with the result that the
contents in the lumen are mostly fluid and exceed the absorptive capacity of the colon. Also, with
those diseases where there is decreased protein breakdown (pancreatic insufficiency, Ostertagia in
cattle), the big old osmotic proteins just stay in the lumen all the way through, and drag water with
them.
A condition commonly encountered in the intestine is villus atrophy. This means that the villi are
shorter (and sometimes wider) than they should be. The net result is decreased absorptive area
and diarrhea.
Malabsorptive diarrheaDecreased absorption of solutes from the lumen occurs in villus atrophy, just because there is not enough surface area to do the required work. The solutes and electrolytes that are not absorbedcause water to be osmotically attracted into the lumen from the mucosa, with the result that thecontents in the lumen are mostly fluid and exceed the absorptive capacity of the colon. Also, withthose diseases where there is decreased protein breakdown (pancreatic insufficiency, Ostertagia incattle), the big old osmotic proteins just stay in the lumen all the way through, and drag water withthem.A condition commonly encountered in the intestine is villus atrophy. This means that the villi areshorter (and sometimes wider) than they should be. The net result is decreased absorptive areaand diarrhea.
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