Background: The contact allergic reactions from p‑phenylenediamine (PPD) in hair dyes vary from mild
contact dermatitis to severe life‑ threatening events (angioedema, bronchospasm, asthma, renal impairment).
Objectives: To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis.
Materials and Methods: Eighty (M: F 47:33) consecutive patients aged between 18 and 74 years suspected
to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including
p‑phenylenediamine (PPD, 1.0% pet). Results: 54 Fifty‑four (M: F 21:33) patients showed positive patch tests
from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix,
paraben mix, or colophony. Fifty‑seven (71%) patients affected were aged older than 40 years. The duration of
dermatitis varied from 1 year with exacerbation following hair coloring. Forty‑nine patients had
dermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis,
chronic actinic dermatitis, and erythema multiforme‑like lesions were seen in 4, 2, and 1 patients, respectively.
Conclusions: Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent need
for creating consumer awareness regarding hair‑dyes contact sensitivity and the significance of performing
sensitivity testing prior to actual use.
Background: The contact allergic reactions from p‑phenylenediamine (PPD) in hair dyes vary from mildcontact dermatitis to severe life‑ threatening events (angioedema, bronchospasm, asthma, renal impairment).Objectives: To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis.Materials and Methods: Eighty (M: F 47:33) consecutive patients aged between 18 and 74 years suspectedto have contact allergy from hair dye were studied by patch testing with Indian Standard Series includingp‑phenylenediamine (PPD, 1.0% pet). Results: 54 Fifty‑four (M: F 21:33) patients showed positive patch testsfrom PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix,paraben mix, or colophony. Fifty‑seven (71%) patients affected were aged older than 40 years. The duration ofdermatitis varied from <1 month to >1 year with exacerbation following hair coloring. Forty‑nine patients haddermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis,chronic actinic dermatitis, and erythema multiforme‑like lesions were seen in 4, 2, and 1 patients, respectively.Conclusions: Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent needfor creating consumer awareness regarding hair‑dyes contact sensitivity and the significance of performingsensitivity testing prior to actual use.
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