Left: Imaging vs time. SKBR3 (HER2+) cells are shown in top row on left. SKBR3 (HER2+) and MCF10A (HER2-) cells are shown in bottom panel on left with the number of nanoshells bound as a function of time for HER2+ cells. Right: tissue imaging. Preliminary reflectance imaging of normal (top) and HER2+ cancerous tissue (bottom) both after incubation with HER2+ nanoshells. Far right (last column): 30 micron sections of HER2+ cancerous tissue shown in brightfield (top) and darkfield (bottom) after 5 minute incubation.