Prothrombin complex
Prothrombin complex comes in a variety of formulations, all of which contain some combination of vitamin K–dependent coagulation factors. Three-factor prothrombin complex formulations contain factor II, IX, and X. Four-factor prothrombin complex formulations contain factor II, VII, IX, and X. Both 3- and 4-factor formulations also contain variable amounts of protein C and S. Several studies have compared PCC with FFP and vitamin K for reversal of pharmacologic coagulopathy after injury or in anticipation of emergent surgery or invasive procedures. These studies uniformly found that prothrombin complex was faster and more efficacious than FFP and vitamin K at correcting international normalized ratio (INR) without any significant increase in complications.