The initial step of its toxicity is formation of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) by cytochorom P450 which at therapeutic doses is removed by conjugation with gluthation solfidryle (GSH)
The initial step of its toxicity is formation of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) by cytochorom P450 which at therapeutic doses is removed by conjugation with gluthation solfidryle (GSH)