Experimental protocol: All rats were randomly
divided into 6 groups (8 in each group). Group I: shamoperated
group. Group II: Vehicle (2% SCMC), which
used as vehicle to a desired concentration. Group III:
Vitamin C, a well-known antioxidant showing memory
improvement, was orally administered at dose of 250
mg kg-1 BW and served as positive control. Group IVVI:
Rats were treated with different doses of the
alcoholic extract of KP (100, 200 and 300 mg kg-1
BW), respectively. The doses of KP were selected on
the basis of previous studies conducted in laboratory
and those reported in literature.
All rats were orally assigned substances via the
intragastric feeding tube once daily for 14 days before
and 7 days after MCAO. Spatial memory was assessed at
7th day after MCAO. Later on, the KP at dose produced
optimum changes on learning memory was selected for
further evaluation of Malondialdehyde (MDA) levels and
the densities of survival neurons in hippocampus.
Experimental protocol: All rats were randomlydivided into 6 groups (8 in each group). Group I: shamoperatedgroup. Group II: Vehicle (2% SCMC), whichused as vehicle to a desired concentration. Group III:Vitamin C, a well-known antioxidant showing memoryimprovement, was orally administered at dose of 250mg kg-1 BW and served as positive control. Group IVVI:Rats were treated with different doses of thealcoholic extract of KP (100, 200 and 300 mg kg-1BW), respectively. The doses of KP were selected onthe basis of previous studies conducted in laboratoryand those reported in literature.All rats were orally assigned substances via theintragastric feeding tube once daily for 14 days beforeand 7 days after MCAO. Spatial memory was assessed at7th day after MCAO. Later on, the KP at dose producedoptimum changes on learning memory was selected forfurther evaluation of Malondialdehyde (MDA) levels andthe densities of survival neurons in hippocampus.
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