these included Omp25, SOD, IalB,
and InvB. OMVs purified from B. melitensis 16 M and
from VTRM1 (a rough mutant derived from strain 16 M)
were used to vaccinate mice; live vaccine strain B. melitensis
Rev1 was used as a positive control. Results showed no
significant difference in the protection afforded to groups
vaccinated with Brucella OMVs versus those vaccinated
with the live vaccine B. melitensis Rev1. These results were
notable as OMVs are acellular entities, while B. melitensis
Rev1 is a live attenuated vaccine. The live vaccines used to
control animal brucellosis have the ability to infect veterinarians,
animal care workers, and slaughter house workers
accidentally and cause low levels of abortions when given
to pregnant cows.
these included Omp25, SOD, IalB,
and InvB. OMVs purified from B. melitensis 16 M and
from VTRM1 (a rough mutant derived from strain 16 M)
were used to vaccinate mice; live vaccine strain B. melitensis
Rev1 was used as a positive control. Results showed no
significant difference in the protection afforded to groups
vaccinated with Brucella OMVs versus those vaccinated
with the live vaccine B. melitensis Rev1. These results were
notable as OMVs are acellular entities, while B. melitensis
Rev1 is a live attenuated vaccine. The live vaccines used to
control animal brucellosis have the ability to infect veterinarians,
animal care workers, and slaughter house workers
accidentally and cause low levels of abortions when given
to pregnant cows.
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