Cell therapy can increase wound healing rate, reduce scar contracture, and minimize donor-site morbidity in treatment of acute wound [2]. In the treatment of chronic wounds, attempts are made to convert the wound bed into the environment where maximum wound healing can be achieved by transplanting cells with an excellent wound healing capacity to the wound bed [2].
The original and classical view of adipose tissue as a rather specialized passive storage organ has been changed dramatically [3]. The adipose tissue bears several properties that are advanta- geous for neuronal sprouting and direction and has been used in different areas of surgery in recent decades [4,5]. Apart from adipocytes and pre-adipocytes, the adipose tissue contains microvascular endothelial cells, smooth muscle cells, resident monocytes, lymphocytes and stem cells [6].
In recent years, it has been identified that adipose tissue possesses a population of multi-potent stem cells which can be of benefit for treatment of wound injuries of various kinds [7–12].
Utilizing cultured cells for clinical purposes require FDA- approved facilities and techniques and a lengthy culture period.