number of experiment has been conducted to compare the performance of predictive data mining technique on the same dataset and the outcome reveals the decision tree outperforms and sometime bayesian classification is having similar accuracy as of decision tree but other predictive methods like Neural networks classification based on clustering are not performing well. the second conclusion is that the accuracy of the decision tree and bayesian classification further improves after applying genetic algorithm to reduce the actual data size to get the optimal subset of attribute sufficient for heart disease prediction