1. Check if theUSBaspdriver is properly installed (update it from settings).
2. Recheck the jumpers. Change them if they are weakly connected.
3. Try to change the port, sometimes some ports can malfunction (ex. from port 1 to port 0).
4. Press reset button for 10 seconds.
5. Try to erase current program from progisp compiler, and load flash of hex file again