Interestingly, these subjects experienced major reductions in 8-epi-PGF2 after drinking orange juice. Similar observations were previously reported by others, who showed that plasma
ascorbic acid is depleted in smokers compared with nonsmokers and is repleted by moderate supplementation (51, 54). Moreover,in human studies of cigarette smokers and nonsmokers, a higher
amount of F2-isoprostanes was found in smokers’ urine and plasma (51).