Special Clinical Situations : In neonates, urinary recovery accounts for about 70% of the dose. In infants 75 years the average elimination half-life is usually 2-3 times that in young adults.
In patients with renal or hepatic dysfunction, the pharmacokinetics of ceftriaxone are only minimally altered and the elimination half-life is only slightly increased. lf kidney function alone is impaired, biliary elimination of ceftriaxone is increased; if liver function alone is impaired, renal elimination is increased.