insight into biological function when proteins in a given transcription
module are enriched in more than one localization category.
This allows us to subdivide sets of co-expressed proteins, providing
a level of information that cannot be gleaned solely from their
classification in the same module based on their expression profiles.
For example, proteins in the G1 module (representing processes
coordinated at the G1/S transition) localize to three basic categories:
nucleus, bud/bud neck and spindle pole (Fig. 3c). The basic
functions of proteins in the G1 module, where known, can be
divided by localization; proteins localized to the bud/bud neck are
involved in bud formation, whereas nuclear proteins from this
module are involved mainly in chromosome cohesion, transcription,
and DNA replication, repair and recombination. Thus, given