Get the audience laughing.
In my experience, I've found that opening with a joke always starts a speech off in the right direction. It immediately lightens the mood in the room and helps me relax. There is something about looking out in the audience and seeing smiling faces that helps create a bond -- particularly if I can get the audience to join me in laughing at myself. Laugh at yourself is incredibly self-deprecating, and if you get others to join you in that laughter, then it creates a level of trust. The laughter allows your attendees to break down the wall that forces them to see themselves as vastly different from you.