- Attachement to host receptors probably mediates endocytosis of the virus into the host cell.
- Uncoating, and release of the viral genomic RNA into the cytoplasm.
Viral RNA is translated into two processed polyproteins to produce replication proteins.
- Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
- Subgenomic RNA translation gives rise to the capsid protein precursor.
Assembly of new virus particles.
- Non-lytic virus release and maturation of the capsid by proteolytic cleavages.