2. Reduction of nucleic acid content• Chemical & enzymatic treatments are preferred.• Chemicals which are used includes acidified alcohol, salts, acids & alkalies.• Use of such chemicals leads to formation of lygino-alanine which causes hypersensitivity skin reactions.• Enzymes which are used include ribonuclease & nuclease enzymes .• These enzymes can be used exogenously or can be induced endogenously.