In the second main clade, the two species of Lapanthus form a strongly supported clade (BS 97, PP 1), which is found as the sister group to a clade including Cryptanthus tiradentensis in the first diverging lineage plus the highly-supported group (five species) of Cryptanthus subg. Cryptanthus sensu Ramírez-Morillo (1996) (BS 100, PP 1).