We investigated the skin permeability and various biological activities of porcine homogenate of placenta (HP) with the
highest protein contents (452.89 μg/mg). The content of protein in subcritical extract of HP (SPE) was decreased from the
initial content of 452.9 μg/mg to 262.7 μg/mg at 3 h subcritical extract. The contents of amino type nitrogen (A-N) were
sharply increased from 35.1 μg/mg of initial content to 305.9 μg/mg at 3 h subcritical extract. The HP showed a noticeable
activity in terms of antioxidant capacity for ferric reducing antioxidant power (FRAP) assay and especially for 2,2'-Azinobis-
(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method. HP, SPE-0.5, SPE-2 and SPE-3 showed inhibitory effect on elastase
activities with an IC50 of 46.1, 42.9, 31.6 and 34.7 μg/mL, respectively. SPEs showed more significantly inhibitory effect
than HP (p