Cardiovascular disease is the main cause of mortality
among people with type 2 diabetes mellitus (T2DM)
[1,2]. Accelerated atherosclerosis in these patients is
preceded by endothelial dysfunction, inflammatory
burden, and increased lipid peroxidation, all leading to
enhanced macrophage foam cell formation [2]. In
addition to the average blood glucose concentration,
acute glycemic fluctuations from peaks to nadirs (glucose
variability) may be involved in the development of
diabetic complications [3], as they contribute to the
generation of excessive protein glycation and oxidative
stress [4]. High glucose variability has been shown to be
associated with endothelial dysfunction in patients with
T2DM and optimal metabolic control [5]. Currently, the
mean amplitude of glycemic excursion (MAGE) is one
of the most used methods for detecting significant
swings in glycemia [6], but other tools may be