Crosses are very vital in the development of populations for breeding purposes and the ease with which a parent can cross with other clones is very important in enhancing successful generation of progeny in a breeding programme. Sexual propagation is a promising technique in cassava breeding programmes due to its manifold advantages such as enhanced multiplication rate, longer seed viability, ease of storage and transportation . Another advantage is the high genetic heterogeneity, leading to variation among seedlings which provides the breeder opportunity to select materials with good qualities of the traits of interest. However, one of the major problems militating against breeding of cassava is the difficulty in producing recombinant seeds due to the associated limitations such as inbreeding depression, high abortion rate, low seed germinability and long breeding cycle of the crop. The objective of this study was to assess crossability among six cassava varieties in terms of seed set capability and germinability of the hybrid seeds. Nine hybrid populations were developed using three female and three male parents in a non-reciprocal cross and the resultant seeds were sown in the nursery. Seed set and germinability were recorded. The results showed that seed set and germinability were influenced by the genotypes used as parents. The percentage seed set ranged between 19.9 and 35.5 and the cross, TMS 98/0505 x NR 8083 with highest percentage seed set was about 178% better than the cross, TMS 97/2205 x TMS 30572 with the least percentage seed set. There was variation in compatibility between each female parent and the male parent. Germinability of seeds among the nine crosses ranged between 25.74 and 51.30% indicating that a broad base of variation existed in crossability among the cassava varieties. It is therefore suggested that varieties with high crossability having good qualities of breeder's trait(s) of interest should be used in cassava breeding programmes to enable breeders to generate large populations within a short period.