CONCLUSION• Buffer can be said to be effective if it can maintain the pH of a certain solution from its pH range such that the Phosphate buffer is very good buffer for maintaining the pH of blood which is 7.4 since the maximum pH of the phosphate buffer is 8.4 based from its range thus, buffers like acetate buffer is good for particular solution which has the maximum range of 5.74 and minimum range of 3.74.• Moreover knowing the principle of buffers and the Henderson-Hassellbach equation is very crucial for buffer preparation and for better understanding.