The polymorphism in human handedness just as the relative rarity of left-handers compared to right-handers persists since thousands of years [1], [2]. While recent reports suggest that 10–13% of the western population is left-handed [3], percentages vary, among others, depending on the item used to assess someone’s handedness. For example, according to a large survey the preference of people aged 18–40 years for throwing left-handed ranged from 9.50% to 10.85% in men and from 6.93% to 7.99% in women, respectively, whereas left-handedness for writing was markedly higher (men: 12.14%–14.13%; women: 9.72%–11.85%) [4]. An almost consistent finding across studies is the stronger tendency for left-handedness in males compared to females [5]. A by now unsolved question is how the handedness polymorphism could be maintained despite left-handedness potentially being linked with negative traits such as a higher risk to suffer from health disorders [6]. Negative frequency-dependent selection mechanisms might explain this phenomenon. More specifically, analogous to survival strategies observed in the animal kingdom [7], [8], left-handers might have benefited from a fitness advantage in one-on-one fighting situations due to being rarer compared to right-handers, which, in turn, helped compensate for some of the costs inherent to left-handedness [9].