Results
Biochemical parameters
Serum alkaline phosphatase (ALP) levels in all ibuprofen exposed rats were significantly, P < 0.001 increased, when compared to control rats (Table 1). In addition, while acid phosphatase (ACP) levels were significantly, P < 0.001 increased in rats that received 40 mgkg-1 ibuprofen for 14 and 28 days, ACP levels in all 20 mgkg-1 ibuprofen treated rats, as well as those that received 40 mgkg-1 ibuprofen for 7 days were not significantly different from control (Table 1). Average serum level of alanine transaminase (ALT) in rats that received 40 mgkg-1 ibuprofen for 28 days was significantly, P < 0.05 increased, while there were no changes in ALT levels in all other treated rats, when compared to control rats (Table 2).