The present meta-analysis has several limitations. We realize that our results may have been partially skewed by including the data of the REDOX study10 for its considerable weight on the summary of the analysis. On the contrary, it seems unreasonable to exclude such trial for its strength and scientific robustness including a large and adequate number of patient, blindness, rigorous determination and adjudication of infection, and ITT analysis, all of which augment the validity of the trial. By excluding this RCT, the results of a meta-analysis may artificially appear in favor of the treatment.