Macadamia nuts are a valuable source of nutrients. They contain high levels of monounsaturated fat, and are also a good source of protein, minerals, vitamins, phytosterols, and phenolic compounds. Modern cultivation practices have resulted in a reliable and plentiful supply of macadamia nuts, from countries such as the United States of America and Australia. The nuts are consumed as snacks, and used in ice creams and baked products, while the oil is popular for cooking. There is a growing body of evidence suggesting that macadamia nuts can improve various risk factors for cardiovascular disease, including hypercholesterolemia, body weight, oxidative stress, and inflammation. Macadamia nuts may be useful when consumed alone, or in combination with traditional pharmacotherapy to reduce risk of cardiovascular disease. Long-term health benefits of macadamia nut consumption warrant further investigation.