In the Midwest United States, a voluntary, interprofessional partnership formed as a community response to these urgent obesity-related social and health issues. This partnership developed between local public health departments and clinical health care organizations in a four-county region with racially diverse populations characterized by a high prevalence of poverty and obesity. Their collaborative project addressed clinical practice deficiencies among health care systems, particularly those serving disadvantaged populations, by translating the Institute for Clinical Systems Improvement (ICSI) Prevention and Management of Adult Obesity Guideline into clinical practice. The ICSI Guideline promotes routine assessment of Body Mass Index (BMI); comprehensive assessment of comorbid conditions; and use of motivational interviewing techniques to assess readiness for change to assist in finding reasons for change, and build confidence in the ability to change (Fitch et al., 2013).