After 8 weeks of RUV therapy, rats were weighed and killed under diethyl ether by cervical decapitation. Testes and epididymes of each animal were collected, weighed and their relative weights were calculated (relative organ weight = organ weight / body weight × 100).One testis was fixed in 10% formalin for histopathological examination.The other testis was snap-frozen in liquid nitrogen and kept at −80°C for various biochemical analyses.