Literature data indicated that amoxicillin in dilute aqueous solution, was found to follow first order or pseudo first order degradation rate at constant pH with a minimum rate at about pH 6. Amoxicillin degradation was subject to catalysis by phosphate and citrate
buffers with a 10 fold increase in rate with phosphate. Increasing ionic strength was reported to have positive effect on degradation rate in alkali and a negative effect in acid