Increasing
quartiles of sESAM were also associated with lower estimated
glomerular filtration rate (eGFR) and lower treadmill exercise capacity
(Table 1). Levels of sESAM were significantly correlated with
other serum biomarkers of disease, with Spearman correlation
coefficients of 0.33 for NT-pro-BNP, 0.61 for cystatin C, -0.6120 for
eGFR, 0.2 for TNF-a, and 0.2 for IL-6 (Table 2) (p < 0.0001 for all).