TREATMENT
The choice of antibiotic depends on the organism isolated. In
most cases the initial treatment has to be empirical, but none-theless based on epidemiological knowledge of the commonest
organisms for each age group and local antibiotic resistance patterns. The chosen antibiotic should have
bactericidal activity in the CSF. Patients with pneumococcal or Gram negative bacillary meningitis who are treated with bacteriostatic antibiotics may have a poor clinical outcome.24 Animal studies have shown that a bactericidal effect is necessary for sterilisation of the CSF and survival