It has been suggested that aged skin has a disturbed barrier function, resulting in a dry appearance of the skin and an enhanced risk on skin disorders (Hashizume, 2004). Another health drawback is the enhanced risk on malignancies (Goukassian and Gilchrest, 2004). Knowledge about the mechanisms of skin aging is important to develop better skin care products that slow down skin aging and reduce the hazardous effects of aging (Farage et al., 2008 and Elsner et al., 2011).