Fully quantitative
PET methods need not only the measure tissue activity but also
the amount of radiotracer delivered to the tissue during the PET
scanning period. The gold standard to obtain the input function is to
measure the radiotracer activity in the arterial blood samples. In
this study, a 2-compartment model was used to describe the regional
18F-FDG transport and phosphorylation rates as shown in The boundary between the plasma compartment
and tissue's 18F-FDG compartment represents the BBB for the
transport of 18F-FDG. The boundary between the compartments of
tissue's 18F-FDG and tissue's 18F-FDG-6P represents the enzyme