Taccone and colleagues demonstrated that, despite maintained mean arterial pressure, cerebral microvascular impair-ment occurred in sepsis. In an animal model of sheep peritonitis, the authors used the sidestream dark field videomicroscopy technique to show that sepsis induced decreases in cerebral total perfused vessel density, functional capillary density, the proportion of small per-fused vessels, and the number of perfused capillaries.