The approach to sample size estimation for paired binarydata depends on the nature of your research question. Inturn, this will determine the approach to statistical analyses.For analyses based on a subject-specific approach, werecommend estimating sample size based on the asymptoticunconditional McNemar test. Even for analyses based on aGEE approach to binary logistic regression, in the specialcase of a 22 table, the asymptotic unconditional McNe-mar test can be used to estimate sample size. We do notrecommend using an exact McNemar test.