The effect of immune modulation of BBB transporters can take
several forms. In the cases of insulin, leukemia inhibitory factor,
and TNF, uptake is dramatically enhanced because blood-to-brain
transporters specific or selective for these substances have
increased activity. The enhanced transport is independent of any
disruption that occurs. In the cases of amyloid beta peptide, verapamil,
most anti-seizures drugs, and many anti-virals, uptake is
enhanced because brain-to-blood transporters for these substances
have decreased activity (Deane et al., 2004; Ronaldson et al., 2008).
One transporter whose response to TNF and LPS has been well
worked out is that of P-gp. LPS acts directly on the brain endothelial
cell (BEC) and all the components of the reaction are mediated
through pathways contained within the BEC
The effect of immune modulation of BBB transporters can takeseveral forms. In the cases of insulin, leukemia inhibitory factor,and TNF, uptake is dramatically enhanced because blood-to-braintransporters specific or selective for these substances haveincreased activity. The enhanced transport is independent of anydisruption that occurs. In the cases of amyloid beta peptide, verapamil,most anti-seizures drugs, and many anti-virals, uptake isenhanced because brain-to-blood transporters for these substanceshave decreased activity (Deane et al., 2004; Ronaldson et al., 2008).One transporter whose response to TNF and LPS has been wellworked out is that of P-gp. LPS acts directly on the brain endothelialcell (BEC) and all the components of the reaction are mediatedthrough pathways contained within the BEC
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